Metronidazole CAS 443-48-1

CAS: 443-48-1

Molecular Formula: C6H9N3O3

Molecular Weight: 171.15

EINECS: 207-136-1

Synonyms: TIMTEC-BB SBB001486; 1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole; 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole; 1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole; 1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole; 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-; 1H-Imidazole-1-ethanol,2-methyl-5-nitro-; 1-Hydroxyethyl-2-methyl-5-nitroimidazole; 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethanol; 2-Methyl-1-(2-hydroxyethyl)-5-nitroimidazole

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What is Metronidazole CAS 443-48-1?

Metronidazole is a white or slightly yellow crystalline or crystalline powder; There is a slight odor, with a bitter and slightly salty taste. Slightly soluble in ethanol, slightly soluble in water or chloroform, and extremely slightly soluble in ether. Metronidazole is a nitrogen-containing heterocyclic compound with alkalinity and low water solubility. According to the prodrug principle, metronidazole is made into potassium phosphate ester, which increases its water solubility and can be used as an injection solution.

Specification

Item	Specification
Boiling point	301.12°C (rough estimate)
Density	1.3994 (rough estimate)
Melting point	159-161 °C (lit.)
pKa	pKa 2.62(H2O,t =25±0.2,
Storage conditions	2-8°C

Application

Metronidazole has a strong antibacterial effect on most anaerobic bacteria and is used to treat amoebiasis, trichomoniasis, and anaerobic bacterial infections. It is also used to treat vaginal trichomoniasis and has been used for intestinal and extraintestinal amoebiasis since 1970. Its efficacy is high, toxicity is low, and it is widely used. Has mutagenic and teratogenic effects on animal experiments.