Celastrol CAS 34157-83-0

CAS: 34157-83-0

Molecular Formula: C29H38O4

Molecular Weight: 450.61

EINECS: 636-472-5

Synonyms: CELASTROL(SH); CELASTROL; Celastrol (Tripterin); CELASTROL(P)(PLEASE CALL); (20R)-3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid; 2-Oxo-3-hydroxy-24-norfriedela-1(10),3,5,7-tetraene-29-oic acid; 2-Oxo-3-hydroxy-24-norfriedelane-1(10),3,5,7-tetraene-29-oic acidCelasterol

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What is Celastrol CAS 34157-83-0?

Celastrol is insoluble in water, soluble in dimethyl sulfoxide and anhydrous ethanol. Derived from anti-cancer active ingredients in plants such as Thunder God Vine and South Snake Vine in the family Celastraceae. An effective proteasome inhibitor, confirmed to induce cancer cell apoptosis by inhibiting proteasome activity

Specification

Item	Specification
Boiling point	645.7±55.0 °C(Predicted)
Density	1.2
Melting point	219-230°C
pKa	4.78±0.70(Predicted)
λmax	424nm(MeOH)(lit.)
Storage conditions	-20°C

Application

Celastrol is used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: It has strong antioxidant properties, anti-cancer angiogenesis effects, and anti rheumatoid effects. An effective proteasome inhibitor, confirmed to induce cancer cell apoptosis by inhibiting proteasome activity